Division of Environmental Medicine, Norwegian Institute of Public Health, Nydalen, Oslo, Norway.
Br J Nutr. 2012 Feb;107(3):436-44. doi: 10.1017/S0007114511003047. Epub 2011 Jul 18.
Results from previous studies on associations between maternal fish and seafood intakes and fetal growth are inconclusive. The aim of the present study was to investigate how maternal intakes of seafood, subtypes of seafood and supplementary n-3 fatty acids were associated with infant birth weight, length and head circumference in a prospective study in Norway. The study population included 62 099 participants in the Norwegian Mother and Child Cohort Study. The mothers answered an FFQ in mid pregnancy. The FFQ comprised detailed questions about intake of various seafood items and n-3 supplements. Data on infant birth weight, length and head circumference were obtained from the Medical Birth Registry. We used multivariable regression to examine how total seafood, various seafood subtypes and supplementary n-3 intakes were associated with birth size measures. Total seafood intake was positively associated with birth weight and head circumference. Lean fish was positively associated with all birth size measures; shellfish was positively associated with birth weight, while fatty fish was not associated with any birth size measures. Intake of supplementary n-3 was negatively associated with head circumference. The relative risk of giving birth to a small baby ( < 2500 g) in full-term pregnancies was significantly lower in women who consumed >60 g/d of seafood than in women who consumed ≤ 5 g/d (OR = 0·56 (95 % CI 0·35, 0·88). In conclusion, maternal seafood consumption was positively associated with birth size, driven by lean fish intake, while supplementary n-3 intake was negatively associated with infant head circumference.
先前关于母体鱼类和海鲜摄入量与胎儿生长之间关联的研究结果尚无定论。本研究旨在探讨挪威一项前瞻性研究中，母体海鲜、海鲜亚类和补充 n-3 脂肪酸的摄入量与婴儿出生体重、长度和头围之间的关系。该研究人群包括挪威母婴队列研究中的 62099 名参与者。母亲在妊娠中期回答了一份 FFQ。FFQ 包含了关于各种海鲜和 n-3 补充剂摄入量的详细问题。婴儿出生体重、长度和头围的数据来自医疗出生登记处。我们使用多变量回归来检查总海鲜、各种海鲜亚类和补充 n-3 摄入量与出生大小指标的关系。总海鲜摄入量与出生体重和头围呈正相关。瘦鱼与所有出生大小指标均呈正相关；贝类与出生体重呈正相关，而肥鱼与任何出生大小指标均无关联。补充 n-3 的摄入量与头围呈负相关。在足月妊娠中，食用 >60 克/天海鲜的女性生出小婴儿（<2500 克）的相对风险明显低于食用≤5 克/天的女性（OR=0.56（95%CI 0.35,0.88））。总之，母体海鲜摄入量与出生体重呈正相关，这主要归因于瘦鱼的摄入量，而补充 n-3 的摄入量与婴儿头围呈负相关。
