Section of Neuropsychiatry, Department of Psychiatry, Dartmouth Medical School, Lebanon, NH 03756, USA.
Int J Psychophysiol. 2011 Oct;82(1):107-14. doi: 10.1016/j.ijpsycho.2011.06.022. Epub 2011 Jul 19.
Alterations in working memory (WM) are common after traumatic brain injury (TBI). Frontal catecholaminergic systems, including the alpha-2 adrenergic system, modulate WM function and may be affected in TBI. We hypothesized that administration of an alpha-2 adrenergic agonist might improve WM after mild TBI (MTBI). Thirteen individuals with MTBI 1month after injury and 14 healthy controls (HC) were challenged with guanfacine and placebo prior to administration of a verbal WM functional MRI task. Guanfacine was associated with improved WM performance in the MTBI but not the HC group. On guanfacine the MTBI group showed increased activation within a WM task-specific region of interest. Findings are consistent with the hypothesis that alterations in WM after MTBI may be improved with the alpha-2 agonist guanfacine.
创伤性脑损伤 (TBI) 后常出现工作记忆 (WM) 改变。包括α-2 肾上腺素能系统在内的额皮质儿茶酚胺能系统调节 WM 功能，在 TBI 中可能受到影响。我们假设，给予α-2 肾上腺素能激动剂可能改善轻度 TBI (MTBI) 后的 WM。13 名 MTBI 患者在损伤后 1 个月和 14 名健康对照 (HC) 接受胍法辛和安慰剂治疗，然后进行言语 WM 功能磁共振成像任务。胍法辛与 MTBI 组的 WM 表现改善相关，但与 HC 组无关。在胍法辛治疗下，MTBI 组在 WM 任务特异性 ROI 内显示出更高的激活。这些发现与以下假设一致，即 MTBI 后 WM 的改变可能通过α-2 激动剂胍法辛得到改善。
