Müller Sabrina, Dennemärker Julia, Reinheckel Thomas
Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Freiburg, Germany.
Biochim Biophys Acta. 2012 Jan;1824(1):34-43. doi: 10.1016/j.bbapap.2011.07.003. Epub 2011 Jul 13.
Endolysosomal vesicles form a highly dynamic multifunctional cellular compartment that contains multiple highly potent proteolytic enzymes. Originally these proteases have been assigned to cooperate solely in executing the unselective 'bulk proteolysis' within the acidic milieu of the lysosome. Although to some degree this notion still holds true, evidence is accumulating for specific and regulatory functions of individual 'acidic' proteases in many cellular processes linked to the endosomal/lysosomal compartment. Here we summarize and discuss the functions of individual endolysosomal proteases in such diverse processes as the termination of growth factor signaling, lipoprotein particle degradation, infection, antigen presentation, and autophagy. This article is part of a Special Issue entitled: Proteolysis 50 years after the discovery of lysosome.
内溶酶体囊泡形成一个高度动态的多功能细胞区室，其中包含多种高效的蛋白水解酶。最初，这些蛋白酶仅被认为认为认为在溶酶体的酸性环境中协同执行非选择性的“大量蛋白水解”。尽管在某种程度上这一概念仍然成立，但越来越多的证据表明，单个“酸性”蛋白酶在与内体/溶酶体区室相关的许多细胞过程中具有特定和调节功能。在这里，我们总结并讨论了单个内溶酶体蛋白酶在诸如生长因子信号终止、脂蛋白颗粒降解、感染、抗原呈递和自噬等多种过程中的功能。本文是名为：溶酶体发现50年后的蛋白水解的特刊的一部分。
