Chen Yan, Deng Hongxia, Zhang Nannan
Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Key Laboratory of Birth Defects and Women and Children's Diseases, Ministry of Education, Sichuan University, Chengdu, Sichuan Province, China.
Neural Regen Res. 2025 Jul 1;20(7):1864-1882. doi: 10.4103/NRR.NRR-D-23-01948. Epub 2024 May 13.
Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular mechanisms. Past studies have focused on factors that stimulate axonal outgrowth and myelin regeneration. However, recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration, particularly in the context of traumatic injuries. Consequently, autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve regeneration. Our current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths, thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and inflammation. These actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration. A range of autophagy-inducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve injuries. This review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration, summarizing the potential drugs and interventions that can be harnessed to promote this process. We hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.
创伤性周围神经损伤和神经病变后的神经再生是一个由多种因素和复杂分子机制调节的复杂过程。过去的研究主要集中在刺激轴突生长和髓鞘再生的因素上。然而，最近的研究强调了自噬在周围神经再生中的关键作用，特别是在创伤性损伤的背景下。因此，靶向自噬的调节已成为一种有前景的治疗方法，以促进周围神经再生。我们目前的理解是，激活自噬有助于快速清除受损的轴突和髓鞘，从而提高神经元的存活率，并减轻损伤诱导的氧化应激和炎症。这些作用共同有助于为神经的结构和功能再生创造有利的微环境。一系列诱导自噬的药物和干预措施已在创伤性周围神经损伤的临床前模型中显示出在减轻周围神经病变和促进神经再生方面的有益效果。本综述深入探讨了参与周围神经再生的细胞类型中自噬的调节，总结了可用于促进这一过程的潜在药物和干预措施。我们希望我们的综述将为利用自噬途径治疗周围神经损伤和神经病变提供新的见解和观点。
