Dipartimento di Biotecnologie, Università degli Studi di Siena, SI, Italy.
J Proteomics. 2011 Oct 19;74(11):2324-37. doi: 10.1016/j.jprot.2011.06.029. Epub 2011 Jul 13.
Environmental pollutants, such as compounds used in agriculture or deriving from vehicles, industries and human activities, can represent major concern for human health since they are considered to contribute significantly to many diseased states with major public health significance. Besides considerable epidemiological evidence linking environmental pollutants with adverse health effects, little information is provided on the effects of these compounds at the cellular and molecular level. Though oxidative stress is generally acknowledged as one of the most important mechanisms of action for pollutant-induced toxicity, redox proteomics, the elective tool to identify post-translationally oxidized proteins, is still in its very infancy in this field of investigation. This review will provide the readers with an outline of the use of redox proteomics in evaluating pollutant-induced oxidative damage to proteins in various biological systems. Future potential applications of redox proteomic approaches from an environmental point of view will be discussed as well.
环境污染物，如农业中使用的化合物或源自车辆、工业和人类活动的化合物，可能对人类健康构成重大威胁，因为它们被认为是许多具有重大公共卫生意义的疾病状态的重要诱因。除了将环境污染物与不良健康影响联系起来的大量流行病学证据外，关于这些化合物在细胞和分子水平上的影响的信息很少。尽管氧化应激通常被认为是污染物引起的毒性的最重要作用机制之一，但作为鉴定翻译后氧化蛋白的选择性工具的氧化还原蛋白质组学在这一研究领域仍处于起步阶段。本文综述了氧化还原蛋白质组学在评估各种生物系统中污染物诱导的蛋白质氧化损伤中的应用。还将讨论从环境角度来看氧化还原蛋白质组学方法的未来潜在应用。
