Department of Virology, Haartman Institute, University of Helsinki, Finland.
J Neuroimmunol. 2011 Aug 15;237(1-2):93-7. doi: 10.1016/j.jneuroim.2011.06.012. Epub 2011 Jul 20.
Demyelinating diseases of the central nervous system (CNS) often include elevated IgG production in intrathecal space presenting as oligoclonal bands (OCBs) in cerebrospinal fluid (CSF). In most demyelinating diseases, e.g. in multiple sclerosis (MS), the underlying cause is not known. We used isoelectric focusing and affinity immunoblot to study the specificity of CSF OCBs to human herpesvirus-6 (HHV-6) in patients with demyelinating diseases of the CNS including MS. Eighty patients with positive OCB finding were included in the study. The OCBs reacted with the HHV-6 antigen in 18 cases (23%). Twelve of 46 MS patients (26%), 5 of 24 other demyelinating diseases (21%) and 1 of 10 other neurological disorders (10%) had HHV-6 specific OCBs in CSF. A specific intrathecal HHV-6 A and B antibody production was shown in a proportion of patients with demyelinating diseases and might suggest a role in the pathogenesis of these diseases.
中枢神经系统（CNS）脱髓鞘疾病常伴有鞘内 IgG 产量升高，在脑脊液（CSF）中表现为寡克隆带（OCB）。在大多数脱髓鞘疾病中，如多发性硬化症（MS），其根本原因尚不清楚。我们使用等电聚焦和亲和免疫印迹来研究中枢神经系统脱髓鞘疾病患者脑脊液 OCB 对人类疱疹病毒-6（HHV-6）的特异性，包括 MS。在这项研究中，我们纳入了 80 名 OCB 阳性发现的患者。在 18 例（23%）患者中，OCB 与 HHV-6 抗原反应。在 46 名 MS 患者中（26%），12 名患者、24 名其他脱髓鞘疾病患者（21%）和 10 名其他神经系统疾病患者（10%）的 CSF 中有 HHV-6 特异性 OCB。脱髓鞘疾病患者中存在特定的鞘内 HHV-6 A 和 B 抗体产生，这可能提示其在这些疾病的发病机制中起作用。
