Martiny L, Antonicelli F, Thuilliez B, Lambert B, Jacquemin C, Haye B
Biochimie, Faculté des Sciences, Reims, France.
Cell Signal. 1990;2(1):21-7. doi: 10.1016/0898-6568(90)90029-a.
The increased turnover of phosphatidylinositol promoted by thyrotropin (TSH) in pig thyroid tissue does not seem to be caused by an increased production of inositol tris-phosphate. We have explored another possibility, the synthesis of an inositol phosphate-glycan (IP-gly). Our results show that thyroid cells in culture produced this substance from a precursor phosphatidylinositol-glycan (Gly-PI). The obtained IP-gly seemed, by its analytical and biological properties, to be identical, or similar, to the previously described insulin mediator.
促甲状腺素（TSH）所促进的猪甲状腺组织中磷脂酰肌醇周转率的增加似乎并非由三磷酸肌醇产量的增加所致。我们探究了另一种可能性，即肌醇磷酸聚糖（IP-聚糖）的合成。我们的结果表明，培养中的甲状腺细胞由前体磷脂酰肌醇聚糖（Gly-PI）产生了这种物质。根据其分析和生物学特性，所获得的IP-聚糖似乎与先前描述的胰岛素介质相同或相似。
