Old Age Psychiatry Directorate, Royal Cornhill Hospital, UK.
QJM. 2011 Nov;104(11):913-20. doi: 10.1093/qjmed/hcr118. Epub 2011 Jul 18.
The burden of medical comorbidity in individuals with Alzheimer's disease is greater than that observed in matched individuals without dementia. This has important implications for all clinicians and healthcare providers who deal with this common condition. The prevalence of vascular risk factors and vascular disease is particularly high. Additionally, associations with a number of other chronic medical conditions have been described, including thyroid disorders, sleep apnoea, osteoporosis and glaucoma. This review gives an overview of evidenced medical (non-psychiatric) comorbidity associated with Alzheimer's disease and briefly explores the underlying mechanisms that may account for these associations.
阿尔茨海默病患者的医疗合并症负担比无痴呆的匹配个体更重。这对所有处理这种常见疾病的临床医生和医疗保健提供者都有重要意义。血管危险因素和血管疾病的患病率特别高。此外，还描述了与许多其他慢性疾病的关联，包括甲状腺疾病、睡眠呼吸暂停、骨质疏松症和青光眼。本文综述了与阿尔茨海默病相关的已证实的医学（非精神科）合并症，并简要探讨了可能导致这些关联的潜在机制。
