Tysiewicz-Dudek Marzena, Pietraszkiewicz Franciszek, Drozdzowska Bogna
Specialist Medical Practice, Lubsko.
Ortop Traumatol Rehabil. 2008 Jul-Aug;10(4):315-23.
Both Alzheimer's disease and osteoporosis occur mainly in persons aged over 60. Both diseases are often seen to co-occur in clinical practice, yet very few investigators have addressed this problem. They have demonstrated that several different clinical factors can lead to a higher incidence of osteoporosis in persons with Alzheimer's disease. Serum concentrations of vitamins D and K, calcium and PTH; the duration of sunlight exposure; dietary calcium intake; genetic factors as well as the effect of oestrogens on mineral bone density in patients with and without dementia have been studied. Furthermore, the effects of vitamin D and calcium preparations with or without bisphosphonates (risedronate) have also been assessed. The authors concertedly emphasise that the treatment of patients with dementia needs to include the prophylaxis of osteoporosis, falls and fractures.
阿尔茨海默病和骨质疏松症主要发生在60岁以上的人群中。在临床实践中，这两种疾病常常同时出现，但很少有研究者关注这个问题。他们已经证明，几种不同的临床因素会导致阿尔茨海默病患者骨质疏松症的发病率更高。研究了维生素D和K、钙和甲状旁腺激素的血清浓度；阳光照射时间；饮食钙摄入量；遗传因素以及雌激素对有或无痴呆症患者骨矿物质密度的影响。此外，还评估了维生素D和钙制剂联合或不联合双膦酸盐（利塞膦酸盐）的效果。作者一致强调，痴呆症患者的治疗需要包括预防骨质疏松症、跌倒和骨折。
