Department of Pediatric Radiology and Pediatric Oncohematology, Universidad Autónoma de Barcelona, Barcelona, Spain.
Radiographics. 2011 Jul-Aug;31(4):1123-39. doi: 10.1148/rg.314105180.
The need for early, accurate diagnosis of central nervous system (CNS) complications occurring during and after pediatric cancer treatment is growing because of the improvement in overall survival rates related to innovative and aggressive oncologic therapies. An elevated degree of suspicion is needed to recognize the radiologic features of these CNS complications. Radiologists need familiarity with the early and late side effects of cancer therapy in the pediatric CNS (eg, toxic effects, infection, endocrine or sensory dysfunction, neuropsychologic impairment, second malignancies), in order to accelerate the imaging diagnosis and minimize as much as possible the associated morbidity. Acquisition of knowledge about these complications will enable the development of more appropriate therapeutic trials and more effective patient surveillance and will lead to an improved quality of life by decreasing the long-term sequelae in survivors.
由于创新性和强化性肿瘤治疗相关的整体存活率的提高，对儿科癌症治疗期间和治疗后中枢神经系统（CNS）并发症进行早期、准确诊断的需求日益增长。为了识别这些 CNS 并发症的放射学特征，需要高度怀疑。放射科医生需要熟悉儿科 CNS 中癌症治疗的早期和晚期副作用（例如，毒性作用、感染、内分泌或感觉功能障碍、神经心理障碍、第二恶性肿瘤），以便加速影像学诊断并尽可能减少相关发病率。获得这些并发症的知识将能够开展更合适的治疗试验，并对患者进行更有效的监测，通过减少幸存者的长期后遗症，提高生活质量。
