Kumar Yogesh, Drumsta Douglas, Mangla Manisha, Gupta Nishant, Hooda Kusum, Almast Jeevak, Mangla Rajiv
Department of Radiology, Yale New Haven Health System at Bridgeport Hospital, Bridgeport, CT, U.S.A.
Department of Imaging Sciences, University of Rochester Medical Centre, Rochester NY, U.S.A.
Pol J Radiol. 2017 Jun 13;82:311-319. doi: 10.12659/PJR.901791. eCollection 2017.
Toxic leukoencephalopathy results from damage to the white matter caused by various toxins. It manifests itself as white matter signal abnormalities with or without the presence of restricted diffusion. These changes are often reversible if the insulting agent is removed early, with the exception of posthypoxic leukoencephalopathy that can manifest itself 1-2 weeks after the initial insult. However, many other potential causes of white matter signal abnormalities can mimic the changes of toxic leukoencephalopathy. Thus, familiarity with the causes, clinical presentation and particularly imaging findings of toxic leukoencephalopathy is critical for early treatment and improved prognosis. The purpose of this pictorial essay is to familiarize the reader with the various causes of toxic leukoencephalopathy along with its differential diagnoses and mimics.
中毒性白质脑病是由各种毒素对白质造成损害引起的。其表现为白质信号异常，可伴有或不伴有扩散受限。如果早期去除致病因素，这些改变通常是可逆的，但缺氧后白质脑病除外，它可在初次损伤后1 - 2周出现。然而，许多其他导致白质信号异常的潜在原因可模仿中毒性白质脑病的改变。因此，熟悉中毒性白质脑病的病因、临床表现，尤其是影像学表现，对于早期治疗和改善预后至关重要。本图文综述的目的是让读者熟悉中毒性白质脑病的各种病因及其鉴别诊断和相似病症。
