Miao B L, Liau M Y, Huang R J, Chen S W, Chen T K, Chang S C
National Institute of Preventive Medicine, Department of Health, Taipei, R.O.C.
Zhonghua Yi Xue Za Zhi (Taipei). 1990 Jul;46(1):1-6.
Potency of sixty antitoxic unit was reached after two immunizations in 2-week intervals of rabbits and horses with 10-25 mg Taiwan cobra (Naja naja atra) venom which was detoxified by 0.125% glutaraldehyde. Now this procedure has become a routine antivenine-producing method by which snake bivalent neurotropic antivenine is produced. The stability test showed that Taiwan cobra toxoid kept at 37 degrees C for 40 days, the antigenicity increased by 24% and toxicity decreased by 10% as compared to the toxoid maintained at 4 degrees C.
用0.125%戊二醛解毒的10 - 25毫克台湾眼镜蛇（眼镜蛇）毒液，以两周的间隔对兔和马进行两次免疫后，达到了60个抗毒单位的效力。现在这个程序已成为生产蛇双价神经抗毒素的常规抗蛇毒血清生产方法。稳定性试验表明，台湾眼镜蛇类毒素在37摄氏度下保存40天，与在4摄氏度下保存的类毒素相比，抗原性增加了24%，毒性降低了10%。
