Willman C L, Whittaker M H
University of New Mexico School of Medicine, Albuquerque.
Clin Lab Med. 1990 Dec;10(4):769-96.
Proto-oncogenes and suppressor genes fall into four functional groups: growth factors, growth factor and hormone receptors, signal transducers, and transcriptional regulatory factors. Many of these genes are selectively expressed in myeloid cells and may play a role in normal development of the myeloid lineages. Furthermore, chromosomal rearrangements, deletions, and mutations may disrupt the normal expression or function of these genes, promoting MPD and leukemogenesis. Many of the genes altered by karyotypic abnormalities in myeloid disorders are only beginning to be identified. Future studies undoubtedly will determine the molecular mechanisms whereby these genes, residing at karyotypic breakpoints in myeloid disorders, promote neoplastic transformation of myeloid cells.
生长因子、生长因子和激素受体、信号转导分子以及转录调节因子。这些基因中的许多在髓系细胞中选择性表达，可能在髓系谱系的正常发育中发挥作用。此外，染色体重排、缺失和突变可能会破坏这些基因的正常表达或功能，从而促进骨髓增殖性疾病（MPD）和白血病的发生。髓系疾病中因核型异常而改变的许多基因才刚刚开始被识别。毫无疑问，未来的研究将确定这些位于髓系疾病核型断点处的基因促进髓系细胞肿瘤转化的分子机制。
