Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Int J Geriatr Psychiatry. 2012 May;27(5):539-44. doi: 10.1002/gps.2757. Epub 2011 Jul 18.
The reliability and validity of the Chinese version of the neuropsychiatric inventory (CNPI) in patients with Alzheimer's disease (AD) have not been assessed in mainland China. We do the reliability and validity research about CNPI of mainland China in the present study.
The CNPI was administered to 219 caregivers of patients with AD. Each caregiver was retested 4 weeks after initial testing.
The Cronbach's α coefficient of the total symptom scale was 0.69. The Cronbach's α coefficient of the total caregiver distress subscale was 0.72. The Cronbach's α coefficient of the entire inventory was 0.82. The test-retest coefficients ranged from 0.66 to 0.98 (p < 0.001). Principal axis factoring analysis of the symptom subscale yielded a five-factor solution, which contributed to 67.0% of the cumulative variance. Factor 1, which included aberrant motor behavior, hallucinations, delusion and irritability had the most significant contribution to the cumulative variance. Principal axis factoring analysis of the caregiver distress subscale also yielded a five-factor solution, which contributed to 70.2% of the cumulative variance. Factor 1, which included depression, delusion, sleep/night behavior, aberrant motor behavior and irritability had the most significant contribution to the cumulative variance.
This Chinese version of NPI is a reliable and valid tool for measuring neuropsychiatric disturbances in patients with AD.
尚未在中国大陆地区评估神经精神问卷（CNPI）中文版在阿尔茨海默病（AD）患者中的信度和效度。本研究旨在对 CNPI 进行中国大陆地区的信度和效度研究。
对 219 名 AD 患者的照护者进行 CNPI 测试，每位照护者在初次测试后 4 周进行重测。
总症状量表的 Cronbach's α 系数为 0.69。总照护者困扰子量表的 Cronbach's α 系数为 0.72。整个量表的 Cronbach's α 系数为 0.82。测试-重测系数范围为 0.66 至 0.98（p<0.001）。症状子量表的主轴因子分析得出了五因子解决方案，占累积方差的 67.0%。因子 1 包括异常运动行为、幻觉、妄想和易怒，对累积方差的贡献最大。照护者困扰子量表的主轴因子分析也得出了五因子解决方案，占累积方差的 70.2%。因子 1 包括抑郁、妄想、睡眠/夜间行为、异常运动行为和易怒，对累积方差的贡献最大。
该中文版 NPI 是一种可靠且有效的工具，可用于测量 AD 患者的神经精神障碍。
