Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
J Agric Food Chem. 2011 Sep 14;59(17):9219-25. doi: 10.1021/jf202119m. Epub 2011 Aug 11.
Recycling agricultural resources has become an important issue worldwide promoting the economical value of agricultural production processes. Desugared sugar cane extract (DSE) from Saccharum officinarum is a byproduct obtained during sugar production. Two new neolignan glucosides, saccharnan A (1) and saccharnan B (2), together with 10 known phenolics (3-12) were isolated from DSE, and their structures were elucidated on the basis of NMR spectral analysis. Compounds 3, 4, 8, and 9 showed good activity against DPPH radical (IC(50) ≤ 51.20 μM) and compounds 3-8 and 12 exhibited strong ABTS(+) free radical scavenging activity (IC(50) ≤ 51.57 μM) compared to those of the positive controls, ascorbic acid and Trolox. Moreover, compounds 7 and 12 acted as potent tyrosinase inhibitors (IC(50) ≤ 42.59 μM) compared to the positive control arbutin. Our results highlighted the economical value of recycling DSE for the future development of natural antioxidants and/or tyrosinase inhibitors.
农业资源的回收再利用已成为全球范围内的一个重要议题，有助于提升农业生产过程的经济价值。甘蔗糖蜜提取物（DSE）是制糖过程中的副产物，来源于甘蔗（Saccharum officinarum）。从 DSE 中分离得到了两种新的苯丙素葡萄糖苷，即 saccharnan A（1）和 saccharnan B（2），以及 10 种已知的酚类化合物（3-12）。基于 NMR 光谱分析确定了它们的结构。化合物 3、4、8 和 9 对 DPPH 自由基表现出良好的活性（IC50≤51.20 μM），化合物 3-8 和 12 对 ABTS+自由基具有很强的清除活性（IC50≤51.57 μM），优于阳性对照抗坏血酸和 Trolox。此外，化合物 7 和 12 对酪氨酸酶的抑制活性（IC50≤42.59 μM）强于阳性对照熊果苷。研究结果突出了回收 DSE 的经济价值，有助于未来开发天然抗氧化剂和/或酪氨酸酶抑制剂。
