Neuropsychology and Functional Neuroimaging Research Unit, Université Libre de Bruxelles, Brussels, Belgium.
Eur J Neurol. 2011 Dec;18(12):1432-4. doi: 10.1111/j.1468-1331.2011.03477.x. Epub 2011 Jul 19.
To evaluate in disorders of consciousness (DOC) circadian variations in motor patterns and their possible synchronization with physiologically regulated light variations and/or a social environmental factor, i.e. presence and actions of other persons.
Actimetric and ambient light levels recordings were obtained during 4-9 days in two patients with traumatic brain injury (TB1 and TB2) in a minimally conscious state (MCS), one MCS (AI1) and one comatose (AI2) anoxic-ischaemic patients. Environmental changes were automatically recorded using a video system.
Minute light variations correlated with motor activity in all patients. However, motor activity was significantly higher during day than nighttime and correlated with social environmental changes, in patients TB1 and TB2 only.
Night-day circadian variations in motor activity patterns and influence of social stimulations were observed in traumatic MCS patients only. Nonetheless, rapid light variations may temporarily promote increased arousal, and consequently motor activity, in all DOCs.
评估意识障碍（DOC）患者运动模式的昼夜节律变化，及其与生理调节的光照变化和/或社会环境因素（即他人的存在和活动）的可能同步性。
对两名创伤性脑损伤（TB1 和 TB2）所致处于最小意识状态（MCS）、一名 MCS（AI1）和一名缺氧缺血性昏迷（AI2）患者进行了为期 4-9 天的活动记录仪和环境光照水平记录。使用视频系统自动记录环境变化。
所有患者的微小光照变化都与运动活动相关。然而，仅在 TB1 和 TB2 患者中，运动活动在白天明显高于夜间，并与社会环境变化相关。
仅在创伤性 MCS 患者中观察到运动活动模式的昼夜节律变化和社会刺激的影响。尽管如此，快速的光照变化可能会暂时促进所有 DOC 患者的觉醒增加，从而导致运动活动增加。
