Institute of Pharmaceutical Sciences, Kurukshetra University, Haryana, India.
Asian Pac J Trop Med. 2011 May;4(5):347-52. doi: 10.1016/S1995-7645(11)60101-6. Epub 2011 Jun 22.
To investigate antidiabetic, hypolipidemic histopathological analysis of Dillenia indica (D. indica) methanolic leaves (DIME) extract in alloxan induced diabetic rat by administering oral doses (250 and 500 mg/kg body weight).
Blood glucose levels were measured using blood glucose test strips with elegance glucometer on weekly intervals till the end of study (i.e. 3 weeks). Other parameters e.g. liver profile, renal profile and total lipid levels were determined in normal and alloxan induced diabetic rats after oral administration of the extract for 21 days. Histopathological changes in diabetic rat organs (pancreas, liver and kidney) were also observed after extract treatment.
Daily oral administration DIME (250 and 500 mg/kg body weight) and glibenclamide (10 mg/kg) showed beneficial effects on blood glucose level (P < 0.001) as well as improving kidney, liver functions and hyperlipidaemia due to diabetes. The extract treatment also showed to enhanced serum insulin level and body weight of diabetic rats as compared to diabetic control group. Furthermore, the extract has a favorable effect on the histopathological changes of the pancreas, liver and kidney in alloxan induced diabetes.
D. indica possess antidiabetic property as well improve body weight, liver profile, renal profile and total lipid levels. DIME has also favorable effect to inhibit the histopathological changes of the pancreas and kidney in alloxan induced diabetes.
研究杨梅（D. indica）甲醇叶（DIME）提取物对糖尿病大鼠的降血糖、降血脂的组织病理学分析，通过给予口服剂量（250 和 500mg/kg 体重）。
每周使用血糖仪上的血糖测试条测量血糖水平，直至研究结束（即 3 周）。在口服提取物 21 天后，还测定正常和糖尿病大鼠的肝脏谱、肾脏谱和总脂质水平等参数。还观察了提取物治疗后糖尿病大鼠器官（胰腺、肝脏和肾脏）的组织病理学变化。
DIME（250 和 500mg/kg 体重）和格列本脲（10mg/kg）的每日口服给药对血糖水平（P<0.001）以及改善糖尿病引起的肾脏、肝功能和高脂血症均有有益作用。与糖尿病对照组相比，提取物治疗还显示出提高了糖尿病大鼠的血清胰岛素水平和体重。此外，提取物对糖尿病大鼠胰腺、肝脏和肾脏的组织病理学变化有良好的影响。
杨梅具有降血糖作用，能改善体重、肝脏谱、肾脏谱和总脂质水平。DIME 还可抑制糖尿病诱导的胰腺和肾脏的组织病理学变化。
