Center for Molecular Allergology, IDI-IRCCS, Rome, Italy.
Curr Opin Allergy Clin Immunol. 2011 Oct;11(5):438-44. doi: 10.1097/ACI.0b013e32834a41dd.
To define the role of IgE-microarray testing in atopic dermatitis where the multifunctional environmental factors implicated in the pathogenesis of the disease deserve a complex and exhaustive approach for the finest definition of relevant allergenic triggers, if any.
Allergenic factors involved in atopic dermatitis have been reported in inducing atopic dermatitis. Environmental triggers, such as aeroallergens, food allergens, bacterial, and fungal antigen, and the presence of IgE to self-antigens have been described as well. The usefulness of the microarray testing has been preliminary described.
As far as the number of potential triggers or worsening factors in atopic dermatitis is quite broad, we foresee a crucial role for the IgE microarray testing. The microarray testing is helpful in defining all additional reactivity the atopic dermatitis patient could have acquired in her/his allergic life, mostly related to inhalant allergens. Nevertheless, interpretation needs skills and thus this new technology should rather be reserved for the allergologist as it may lead to false conclusions if broadly used in general medicine. IgE microarray testing gives trustable results to define the nonallergic atopic dermatitis form because of the broad and comprehensive negative IgE testing.
在特应性皮炎中，IgE 微阵列检测的作用在于，涉及疾病发病机制的多功能环境因素需要一种复杂而详尽的方法来精细定义相关的变应原触发因素（如果有的话）。
已报道变应性因素参与特应性皮炎的发生。环境触发因素，如空气过敏原、食物过敏原、细菌和真菌抗原，以及自身抗原的 IgE 存在，也已被描述。微阵列检测的有用性已初步描述。
鉴于特应性皮炎的潜在触发因素或恶化因素数量相当广泛，我们预计 IgE 微阵列检测将发挥关键作用。微阵列检测有助于确定特应性皮炎患者在其过敏生活中可能获得的所有其他反应性，主要与吸入性过敏原有关。然而，解释需要技巧，因此，这项新技术应保留给过敏学家使用，因为如果在普通医学中广泛使用，可能会导致错误的结论。IgE 微阵列检测通过广泛而全面的阴性 IgE 检测，为确定非过敏性特应性皮炎形式提供了可靠的结果。
