Division of Research on Children, Youth, and Families, Children's Hospital Los Angeles, Los Angeles, USA.
School of Nursing, Duke University, Durham, USA.
Sci Rep. 2021 Feb 11;11(1):3609. doi: 10.1038/s41598-021-82329-7.
Electroencephalography (EEG) measures of relative power and coherence are associated with motor experience in infants with typical development, but these relationships have not been assessed in infants born preterm. The goal of our study was to investigate the changing patterns of relative power and coherence in the alpha band during resting state EEG in infants born preterm as they developed the skill of reaching. We collected monthly longitudinal data from fourteen infants born preterm between the adjusted ages of 56 and 295 days for a total of 37 sessions of EEG data. Alpha band power at motor cortices and cross-regional connectivity do not present consistent changing trends at the group level in infants born preterm. Individual level analysis reveals that infants born preterm are a heterogeneous group with subtypes of neural function development, some presenting similar changing trends as observed in the typically developing group while others present atypical patterns. This may be linked to the variability in developmental outcomes in infants born preterm. This study was a critical first step to support EEG as a potential tool for identifying and quantifying the developmental trajectories of neuromotor control in infants born preterm.
脑电图（EEG）的相对功率和相干性测量与典型发育婴儿的运动经验有关，但尚未在早产儿中评估这些关系。我们的研究目的是调查早产儿在发展伸手技能时，静息状态脑电图中阿尔法频段相对功率和相干性的变化模式。我们从 14 名在调整后的年龄为 56 至 295 天之间的早产儿中收集了每月的纵向数据，总共进行了 37 次脑电图数据采集。早产儿的运动皮质和跨区域连接的阿尔法频段功率在组水平上没有呈现出一致的变化趋势。个体水平分析表明，早产儿是一个具有不同神经功能发育亚型的异质群体，一些呈现出与典型发育组相似的变化趋势，而另一些则呈现出非典型模式。这可能与早产儿的发育结果的可变性有关。这项研究是支持脑电图作为一种潜在工具，用于识别和量化早产儿神经运动控制发育轨迹的重要的第一步。
