Pérez-Laguna Vanesa, García-Luque Isabel, Ballesta Sofía, Rezusta Antonio, Gilaberte Yolanda
Max Planck Institute for Evolutionary Biology, 24306 Plön, Germany.
Department of Microbiology, School of Medicine, University of Sevilla and Instituto de Biomedicina de Sevilla (IBIS), 41009 Sevilla, Spain.
Pharmaceuticals (Basel). 2021 Jun 23;14(7):603. doi: 10.3390/ph14070603.
The present review covers combination approaches of antimicrobial photodynamic therapy (aPDT) plus antibiotics or antifungals to attack bacteria and fungi in vitro (both planktonic and biofilm forms) focused on those microorganisms that cause infections in skin and soft tissues. The combination can prevent failure in the fight against these microorganisms: antimicrobial drugs can increase the susceptibility of microorganisms to aPDT and prevent the possibility of regrowth of those that were not inactivated during the irradiation; meanwhile, aPDT is effective regardless of the resistance pattern of the strain and their use does not contribute to the selection of antimicrobial resistance. Additive or synergistic antimicrobial effects in vitro are evaluated and the best combinations are presented. The use of combined treatment of aPDT with antimicrobials could help overcome the difficulty of fighting high level of resistance microorganisms and, as it is a multi-target approach, it could make the selection of resistant microorganisms more difficult.
本综述涵盖了抗菌光动力疗法（aPDT）与抗生素或抗真菌药物联合使用的方法，旨在体外攻击细菌和真菌（包括浮游菌和生物膜形式），重点关注那些引起皮肤和软组织感染的微生物。这种联合疗法可以防止在对抗这些微生物时失败：抗菌药物可以增加微生物对aPDT的敏感性，并防止那些在照射过程中未被灭活的微生物重新生长的可能性；同时，aPDT无论菌株的耐药模式如何都有效，并且其使用不会导致抗菌耐药性的产生。评估了体外的相加或协同抗菌作用，并给出了最佳组合。aPDT与抗菌药物联合治疗的应用有助于克服对抗高耐药性微生物的困难，并且由于这是一种多靶点方法，可能会使耐药微生物的产生更加困难。
