刺天茄（茄科）果实水提取物的免疫调节和促红细胞生成作用。
Immunomodulatory and erythropoietic effects of aqueous extract of the fruits of Solanum torvum Swartz (Solanaceae).
作者信息
Koffuor George A, Amoateng Patrick, Andey Terrick A
机构信息
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kumasi, Ghana.
出版信息
Pharmacognosy Res. 2011 Apr;3(2):130-4. doi: 10.4103/0974-8490.81961.
AIM
The effect of Solanum torvum (Fam: Solanaceae) on delayed type hypersensitivity (DTH) response, hemagglutinating antibody (HA) titer, white blood cells (WBC), red blood cells (RBC) and hemoglobin concentration was investigated in Sprague-Dawley rats to establish immunomodulatory and erythropoietic activity.
MATERIALS AND METHODS
Sheep red blood cells (SRBC)-immunized and challenged rats were treated with Solanum torvum extract, levamisole and dexamethasone. Phenylhydrazine (PHZ)-induced anemia in rats was treated with the extract.
RESULTS
The aqueous Solanum torvum extract and levamisole significantly enhanced DTH response, increased HA titer and WBC count, while dexamethasone significantly decreased DTH response, did not increase HA titer, and did not enhance WBC profile. The extract and Feroglobin, the reference heamatinic, were able to reverse PHZ-induced anemia, and increase the RBCs and Hb concentration above baseline values within 24 days.
CONCLUSION
Solanum torvum extract showed a concentration-dependent immunostimulant and erythropoietic activity.
目的
研究刺茄（茄科）对斯普拉格-道利大鼠迟发型超敏反应（DTH）、血凝抗体（HA）效价、白细胞（WBC）、红细胞（RBC）及血红蛋白浓度的影响，以确定其免疫调节和促红细胞生成活性。
材料与方法
用刺茄提取物、左旋咪唑和地塞米松处理经绵羊红细胞（SRBC）免疫和攻击的大鼠。用该提取物治疗苯肼（PHZ）诱导的大鼠贫血。
结果
刺茄水提取物和左旋咪唑显著增强DTH反应，提高HA效价和WBC计数，而地塞米松显著降低DTH反应，不提高HA效价，也不改善WBC情况。该提取物和参比补血剂Feroglobin能够逆转PHZ诱导的贫血，并在24天内使RBC和Hb浓度高于基线值。
结论
刺茄提取物显示出浓度依赖性的免疫刺激和促红细胞生成活性。
Zotero 插件