Sheth Payal A, Pawar Anil T, Mote Chandrashekhar S, More Chandrakant
School of Pharmacy, Dr. Vishwanath Karad World Peace University, Pune, Maharashtra, India.
School of Pharmacy, Dr. Vishwanath Karad World Peace University, Pune, Maharashtra, India.
J Ayurveda Integr Med. 2021 Apr-Jun;12(2):340-345. doi: 10.1016/j.jaim.2021.02.009. Epub 2021 May 18.
Over two billion people around the world suffer from anemia. Majority of populations are using dietary supplements and herbal medicines for the management of the anemic conditions. Many polyherbal formulations such as RaktavardhakKadha (RK), are available in the Indian market as a nutritional supplement and herbal-based medicine for anemia.
The present study is aimed at investigating antianemic potential of polyherbal formulation, RK, against phenylhydrazine-induced anemia in rats.
RK was subjected to preliminary phytochemical analysis and iron estimation. Anemia was induced by phenylhydrazine administration (40 mg/kg, i.p.) for 2 consecutive days. Antianemic activity of RK was investigated at the dose of 1.8 ml/kg, twice daily for 12 days by estimating blood parameters and pathological changes in liver, heart, spleen and bone marrow.
RK was found to contain saponins, steroids, flavonoids, tannins and phenolic compounds. Iron content was found to be 5 mg/100 ml in RK. Anemia induction by phenylhydrazine injections to rats caused significant decrease in red blood cells (RBCs), hemoglobin and hematocrit. These decreased levels of RBCs, hemoglobin and hematocrit in blood was significantly improved by the treatment with RK. Furthermore, RK restored pathological changes in liver, heart, spleen and bone marrow tissues near to normal.
This study suggests antianemic activity of RK, which can be attributed to its iron content and ability to prevent hemolysis.
全球超过20亿人患有贫血症。大多数人群正在使用膳食补充剂和草药来治疗贫血状况。许多复方草药制剂，如RaktavardhakKadha（RK），在印度市场作为贫血症的营养补充剂和草药药物出售。
本研究旨在调查复方草药制剂RK对苯肼诱导的大鼠贫血的抗贫血潜力。
对RK进行初步植物化学分析和铁含量测定。连续2天腹腔注射苯肼（40mg/kg）诱导贫血。通过估计血液参数以及肝脏、心脏、脾脏和骨髓的病理变化，以1.8ml/kg的剂量、每日两次、共12天研究RK的抗贫血活性。
发现RK含有皂苷、甾体、黄酮类、单宁和酚类化合物。RK中的铁含量为5mg/100ml。给大鼠注射苯肼诱导贫血导致红细胞（RBC）、血红蛋白和血细胞比容显著降低。用RK治疗可显著改善血液中RBC、血红蛋白和血细胞比容的降低水平。此外，RK使肝脏、心脏、脾脏和骨髓组织的病理变化恢复至接近正常。
本研究表明RK具有抗贫血活性，这可归因于其铁含量和防止溶血的能力。
