研究炎症性肠病中的肠内微生物组：克服成长中的困难并继续前进。
Studying the Enteric Microbiome in Inflammatory Bowel Diseases: Getting through the Growing Pains and Moving Forward.
机构信息
Department of Medicine, University of Michigan Ann Arbor, MI, USA.
出版信息
Front Microbiol. 2011 Jul 5;2:144. doi: 10.3389/fmicb.2011.00144. eCollection 2011.
Abstract
In this commentary, we will review some of the early efforts aimed at understanding the role of the enteric microbiota in the causality of inflammatory bowel diseases. By examining these studies and drawing on our own experiences bridging clinical gastroenterology and microbial ecology as part of the NIH-funded Human Microbiome Project (Turnbaugh et al., 2007), we hope to help define some of the "growing pains" that have hampered these initial efforts. It is our sincere hope that this discussion will help advance future efforts in this area by identifying current challenges and limitations and by suggesting strategies to overcome these obstacles.
摘要
在这篇评论中，我们将回顾一些早期旨在了解肠内微生物群在炎症性肠病病因中的作用的努力。通过检查这些研究，并借鉴我们自己作为 NIH 资助的人类微生物组计划（Turnbaugh 等人，2007 年）的一部分，在临床胃肠病学和微生物生态学之间架起桥梁的经验，我们希望帮助确定一些阻碍这些最初努力的“成长的烦恼”。我们真诚地希望，通过确定当前的挑战和局限性，并提出克服这些障碍的策略，本次讨论将有助于推动该领域的未来工作。
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