Shavakhi Ahmad, Norinayer Babak, Esteghamat Fateme Sadat, Seghatoleslami Mohamad, Khodadustan Mahsa, Somi Mohamad Hosein, Masoodi Mohsen, Zali Mohamad Reza
Assistant Professor, Department of Internal Medicine, Isfahan University of Medical Science, Isfahan, Iran.
J Res Med Sci. 2009 Jan;14(1):13-7.
Occult hepatitis B is defined as presence of HBV DNA in tissue or serum without hepatitis B surface antigen. The aim of this study is to determine frequency of occult hepatitis B among hepatitis C patients in Tehran and compare the route of transmission and liver enzymes between positive and negative HBV DNA patients.
In a cross sectional study, serum of 103 hepatitis C cases (79.6% men and 20.4% women) were analyzed for s, x and core genes via a nested polymerase chain reaction technique.
HBV DNA was detectable in serum of 20 patients (19.4%). No significant difference in age, sex and route of transmission were seen in HBV DNA positive and negative patients. In HBV DNA positive and negative groups, mean of AST was 73, 47 (p < 0.05) and mean of ALT was 76 and 36 respectively (p < 0.05).
Occult hepatitis B was observed in a considerable number of hepatitis C patients in Tehran. It was associated with elevation in liver enzyme but was not related to route of transmission.
隐匿性乙型肝炎被定义为在组织或血清中存在乙肝病毒DNA但无乙肝表面抗原。本研究的目的是确定德黑兰丙型肝炎患者中隐匿性乙型肝炎的发生率，并比较乙肝病毒DNA阳性和阴性患者的传播途径及肝酶情况。
在一项横断面研究中，采用巢式聚合酶链反应技术对103例丙型肝炎病例（79.6%为男性，20.4%为女性）的血清进行s、x和核心基因分析。
20例患者（19.4%）血清中可检测到乙肝病毒DNA。乙肝病毒DNA阳性和阴性患者在年龄、性别及传播途径方面未见显著差异。在乙肝病毒DNA阳性和阴性组中，谷草转氨酶平均值分别为73和47（p<0.05），谷丙转氨酶平均值分别为76和36（p<0.05）。
在德黑兰相当数量的丙型肝炎患者中观察到隐匿性乙型肝炎。它与肝酶升高有关，但与传播途径无关。
