Yen Eugene F, Pardi Darrell S
Division of Gastroenterology, University of Chicago Pritzker School of Medicine, NorthShore University HealthSystem, 2650 Ridge Avenue, Suite G221, Evanston, IL 60201, USA.
Curr Gastroenterol Rep. 2011 Oct;13(5):458-64. doi: 10.1007/s11894-011-0207-7.
Microscopic colitis is a common cause of chronic diarrhea in predominantly older adults. Incidence rates of microscopic colitis (including lymphocytic and collagenous colitis) have increased over time to levels comparable to other forms of inflammatory bowel disease. The possibility of drug-induced microscopic colitis is an important consideration when evaluating these patients, although this concept requires further investigation. There are few controlled treatment trials in microscopic colitis, with much of the data on treatment coming from retrospective studies. In patients with microscopic colitis, a systematic approach to therapy often leads to satisfactory control of symptoms. In this review, we will provide an updated assessment of the epidemiology, diagnosis, and treatment of microscopic colitis.
显微镜下结肠炎是导致主要为老年人慢性腹泻的常见原因。随着时间的推移，显微镜下结肠炎（包括淋巴细胞性和胶原性结肠炎）的发病率已上升至与其他形式的炎症性肠病相当的水平。在评估这些患者时，药物性显微镜下结肠炎的可能性是一个重要的考虑因素，尽管这一概念需要进一步研究。显微镜下结肠炎的对照治疗试验很少，治疗方面的大部分数据来自回顾性研究。对于显微镜下结肠炎患者，系统的治疗方法通常能使症状得到满意控制。在本综述中，我们将对显微镜下结肠炎的流行病学、诊断和治疗提供最新评估。
