成人肺泡蛋白沉积症的活体供肺叶移植：1 例报告。
Living-donor lobar lung transplantation for pulmonary alveolar proteinosis in an adult: report of a case.
机构信息
Division of Surgical Oncology, Department of Translational Medical Science, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
出版信息
Surg Today. 2011 Aug;41(8):1142-4. doi: 10.1007/s00595-010-4411-0. Epub 2011 Jul 20.
A 43-year-old woman with pulmonary alveolar proteinosis (PAP) was successfully treated with living-donor lobar lung transplantation (LDLLT). The patient's PAP had been diagnosed at age 35. She had been treated with repeated bronchoalveolar lavage and granulocyte-macrophage colony-stimulating factor (GM-CSF) inhalation therapy despite having no serum anti-GM-CSF autoantibodies. At age 42, her respiratory condition became critical and she underwent transplantation from two donors. While careful observation was needed for the recurrence of PAP in the transplanted lungs, she was functioning well without oxygen therapy 1 year after transplantation. This appears to be the first report of LDLLT for PAP in an adult.
一位 43 岁的女性患有肺泡蛋白沉积症（PAP），通过活体供体肺叶移植（LDLLT）成功治疗。该患者在 35 岁时被诊断为 PAP。尽管她没有血清抗 GM-CSF 自身抗体，但她曾接受过多次支气管肺泡灌洗和粒细胞-巨噬细胞集落刺激因子（GM-CSF）吸入治疗。在 42 岁时，她的呼吸状况变得危急，她接受了来自两位供体的移植。虽然需要密切观察移植肺中 PAP 的复发情况，但她在移植后 1 年内无需吸氧治疗，身体状况良好。这似乎是首例成人 PAP 行 LDLLT 的报告。
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