Department of Dermatology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taipei, Taiwan, ROC.
Mol Biol Rep. 2012 Apr;39(4):4111-7. doi: 10.1007/s11033-011-1193-4. Epub 2011 Jul 20.
Psoriasis is a chronic disease characterized by inflammation of the skin. The level of C-reactive protein (CRP), an inflammatory marker that correlates well with the severity of psoriasis, is a heritable trait. This study aimed to assess the role of variations in the CRP gene in patients with psoriasis among the Chinese-Taiwanese. In total, 305 patients with psoriasis and 615 control subjects were analyzed for the presence of the CRP polymorphisms rs2794521, rs3091244, and rs1800947 by polymerase chain reaction. The analysis revealed that neither polymorphism was found to be associated with psoriasis. No significant difference was observed in the genotype and allele distribution for any of the individual CRP polymorphisms between the cases and the controls. The overall haplotype frequency profiles derived from the three polymorphisms did not differ significantly between the cases and the controls. Our results suggest that these three CRP gene polymorphisms may not contribute to the genetic background of psoriasis in Chinese-Taiwanese.
银屑病是一种慢性疾病，其特征为皮肤炎症。C 反应蛋白（CRP）水平是一种与银屑病严重程度密切相关的炎症标志物，其具有遗传性。本研究旨在评估中国台湾汉族人群中 CRP 基因变异在银屑病患者中的作用。共分析了 305 例银屑病患者和 615 例对照者 CRP 基因 rs2794521、rs3091244 和 rs1800947 多态性的存在情况，采用聚合酶链反应法。分析显示，没有发现任何多态性与银屑病有关。在病例组和对照组中，任何一个 CRP 多态性的基因型和等位基因分布均无显著差异。从三个多态性得出的总体单倍型频率图谱在病例组和对照组之间没有显著差异。我们的结果表明，这三个 CRP 基因多态性可能不会导致中国台湾汉族人群银屑病的遗传背景。
