Psoriasis is a chronic disease characterized by inflammation of the skin. The level of C-reactive protein (CRP), an inflammatory marker that correlates well with the severity of psoriasis, is a heritable trait. This study aimed to assess the role of variations in the CRP gene in patients with psoriasis among the Chinese-Taiwanese. In total, 305 patients with psoriasis and 615 control subjects were analyzed for the presence of the CRP polymorphisms rs2794521, rs3091244, and rs1800947 by polymerase chain reaction. The analysis revealed that neither polymorphism was found to be associated with psoriasis. No significant difference was observed in the genotype and allele distribution for any of the individual CRP polymorphisms between the cases and the controls. The overall haplotype frequency profiles derived from the three polymorphisms did not differ significantly between the cases and the controls. Our results suggest that these three CRP gene polymorphisms may not contribute to the genetic background of psoriasis in Chinese-Taiwanese.