Saito Mitsuru, Marumo Keishi
Department of Orthopaedic Surgery, The Jikei University School of Medicine.
Nihon Rinsho. 2011 Jul;69(7):1189-97.
Recently, data have accumulated that collagen cross-link formation in bone affect bone strength. In fact, impaired enzymatic cross-linking and/or an increase in non-enzymatic cross-links, pentosidine (Pen), which is a surrogate marker of advanced glycation end products (AGEs), in bone collagen have been proposed as a major cause of bone fragility in aging, osteoporosis and diabetes mellitus. This review will summarize the mechanism of formation of cross-linking in bone collagen and important aspects of alterations in collagen enzymatic immature and mature cross-links and non-enzymatic senescent type of cross-link (AGEs), in aging, osteoporosis, and diabetes mellitus. We also review recent developments in bone quality-related markers such as serum or urine pentosidine levels and serum homocysteine levels for fracture assessment in patients with osteoporosis and diabetes mellitus.
最近，越来越多的数据表明，骨骼中胶原蛋白交联的形成会影响骨强度。事实上，骨胶原蛋白中酶促交联受损和/或非酶交联（戊糖苷，一种晚期糖基化终产物（AGEs）的替代标志物）增加，已被认为是衰老、骨质疏松症和糖尿病中骨脆性增加的主要原因。本综述将总结骨胶原蛋白交联形成的机制，以及衰老、骨质疏松症和糖尿病中胶原蛋白酶促未成熟和成熟交联以及非酶衰老型交联（AGEs）改变的重要方面。我们还将综述与骨质量相关的标志物（如血清或尿液中戊糖苷水平以及血清同型半胱氨酸水平）在骨质疏松症和糖尿病患者骨折评估中的最新进展。
