[生活方式相关疾病中的骨质量]
[Bone quality in lifestyle-related diseases].
作者信息
Saito Mitsuru, Marumo Keishi
机构信息
Department of Orthopaedic Surgery, Jikei University School of Medicine.
出版信息
Clin Calcium. 2011 May;21(5):655-60.
Lifestyle-related diseases deteriorate bone quality in terms of material properties. Collagen cross-link formation is thought to be a determinant of material strength. Hyperglycemia, oxidative stress, carbonyl stress, and hyperhomocysteinemia induce the reduction in beneficial enzymatic cross-links and the accumulation of disadvantageous non-enzymatic cross-link, Advanced glycation end products (AGEs, Pentosidine) in bone. In this review, we describe that lifestyle-related diseases are crucial determinants of detrimental crosslinking of bone collagen that have been reported in the literature.
生活方式相关疾病会在材料特性方面使骨质量恶化。胶原蛋白交联的形成被认为是材料强度的一个决定因素。高血糖、氧化应激、羰基应激和高同型半胱氨酸血症会导致骨中有益的酶促交联减少以及有害的非酶促交联（晚期糖基化终产物，即骨中的戊糖苷）积累。在本综述中，我们阐述了生活方式相关疾病是文献中报道的骨胶原蛋白有害交联的关键决定因素。
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