Saito Mitsuru, Marumo Keishi
Nihon Rinsho. 2015 Oct;73(10):1665-72.
Bone quality is thought to encompass the structural and material properties of bone. Bone collagen crosslinking plays important roles in bone strength. The quantitative and qualitative deterioration of lysyl oxidase control and non enzymatic cross-links (advanced glycation end products, AGEs, pentosidine) of collagen in patients with osteoporotic femoral neck fracture and diabetes, and chronic kidney disease might be affected by increased oxidative stress and glycation. A higher urinary or plasma pentosidine and homocysteine levels were an independent risk factor for osteoporotic fracture. If confirmed in large, prospective trials, measurements of serum homocysteine and serum or urine levels of pentosidine might be characterized as markers reflecting bone collagen deterioration.
骨质量被认为包括骨骼的结构和材料特性。骨胶原交联在骨强度中起重要作用。骨质疏松性股骨颈骨折、糖尿病和慢性肾病患者中，赖氨酰氧化酶控制以及胶原的非酶交联（晚期糖基化终产物、糖基化终末产物、戊糖苷）的定量和定性恶化可能受到氧化应激和糖基化增加的影响。较高的尿或血浆戊糖苷和同型半胱氨酸水平是骨质疏松性骨折的独立危险因素。如果在大型前瞻性试验中得到证实，血清同型半胱氨酸以及血清或尿液中戊糖苷水平的测量可能被视为反映骨胶原恶化的标志物。
