Hagino Hiroshi
School of Health Science, Faculty of Medicine, Tottori University.
Nihon Rinsho. 2011 Jul;69(7):1253-7.
Bisphosphonates are now one of the standard therapy in the management of osteoporosis. Their significant efficacy in the prevention of vertebral and non-vertebral fractures has been proven. Anti-resorptive potency of bisphosphonates leaded new molecules available either orally or intravenously, from weekly to yearly administration. This review gives an overview of the efficacy as well as the clinical issues of the bisphosphonates.
双膦酸盐目前是骨质疏松症治疗的标准疗法之一。它们在预防椎体和非椎体骨折方面的显著疗效已得到证实。双膦酸盐的抗吸收效力催生了新的分子，这些分子有口服或静脉注射剂型，给药频率从每周一次到每年一次不等。本文综述了双膦酸盐的疗效以及临床问题。
