慢性肝病患者中抗丙型肝炎病毒抗体的流行情况及其与乙型肝炎病毒和丁型肝炎病毒感染的关系。

Prevalence of anti-HCV antibodies in patients with chronic liver disease and its relationship to HBV and HDV infections.

作者信息

Gaeta G B, Rapicetta M, Sardaro C, Spadaro A, Chionne F, Freni A M, Ajello A, Costantino A, Giusti G

机构信息

Dept. of Medicine, c/o Osp. Gesu' e Maria, Naples, Italy.

出版信息

Infection. 1990 Sep-Oct;18(5):277-9. doi: 10.1007/BF01647003.

DOI:10.1007/BF01647003

PMID:2177452

Abstract

The prevalence of anti-HCV, anti-HDV and of HBV markers has been investigated in a series of 209 consecutive patients (age 18-74 years) with chronic liver disease. Among 155 HBsAg negative patients (53 chronic hepatitis cases and 102 cirrhosis cases), anti-HCV were found in 69% of the cases. 67% of the 155 patients also carried anti-HBc, with no difference between patients positive or negative for anti-HCV. Among the 54 HBsAg positive patients, 10 (18.5%) also had anti-HCV, 22 (40.7%) were anti-HDV positive and 12 (22.2%) had serum HBV-DNA. One patient had concomitant anti-HDV and anti-HCV and another presented anti-HCV and serum HBV-DNA. 21/54 patients had liver cirrhosis on presentation and among these 17 (81%) were anti-HCV and/or anti-HDV positive. On the whole, 123/209 patients had liver cirrhosis on presentation and in 107 of them HCV infection may have played a role.

摘要

对连续的209例（年龄18 - 74岁）慢性肝病患者进行了抗丙型肝炎病毒（anti - HCV）、抗丁型肝炎病毒（anti - HDV）及乙肝病毒标志物的流行情况调查。在155例乙肝表面抗原（HBsAg）阴性患者（53例慢性肝炎和102例肝硬化）中，69%的病例检测到anti - HCV。155例患者中有67%同时携带抗乙肝核心抗体（anti - HBc），anti - HCV阳性或阴性患者之间无差异。在54例HBsAg阳性患者中，10例（18.5%）也有anti - HCV，22例（40.7%）anti - HDV阳性，12例（22.2%）血清乙肝病毒脱氧核糖核酸（HBV - DNA）阳性。1例患者同时有anti - HDV和anti - HCV，另1例有anti - HCV和血清HBV - DNA。54例患者中有21例初诊时患有肝硬化，其中17例（81%）anti - HCV和/或anti - HDV阳性。总体而言，209例患者中有123例初诊时患有肝硬化，其中107例丙肝感染可能起了作用。