Gaeta G B, Rapicetta M, Sardaro C, Spadaro A, Chionne F, Freni A M, Ajello A, Costantino A, Giusti G
Dept. of Medicine, c/o Osp. Gesu' e Maria, Naples, Italy.
Infection. 1990 Sep-Oct;18(5):277-9. doi: 10.1007/BF01647003.
The prevalence of anti-HCV, anti-HDV and of HBV markers has been investigated in a series of 209 consecutive patients (age 18-74 years) with chronic liver disease. Among 155 HBsAg negative patients (53 chronic hepatitis cases and 102 cirrhosis cases), anti-HCV were found in 69% of the cases. 67% of the 155 patients also carried anti-HBc, with no difference between patients positive or negative for anti-HCV. Among the 54 HBsAg positive patients, 10 (18.5%) also had anti-HCV, 22 (40.7%) were anti-HDV positive and 12 (22.2%) had serum HBV-DNA. One patient had concomitant anti-HDV and anti-HCV and another presented anti-HCV and serum HBV-DNA. 21/54 patients had liver cirrhosis on presentation and among these 17 (81%) were anti-HCV and/or anti-HDV positive. On the whole, 123/209 patients had liver cirrhosis on presentation and in 107 of them HCV infection may have played a role.
对连续的209例（年龄18 - 74岁）慢性肝病患者进行了抗丙型肝炎病毒（anti - HCV）、抗丁型肝炎病毒（anti - HDV）及乙肝病毒标志物的流行情况调查。在155例乙肝表面抗原（HBsAg）阴性患者（53例慢性肝炎和102例肝硬化）中，69%的病例检测到anti - HCV。155例患者中有67%同时携带抗乙肝核心抗体（anti - HBc），anti - HCV阳性或阴性患者之间无差异。在54例HBsAg阳性患者中，10例（18.5%）也有anti - HCV，22例（40.7%）anti - HDV阳性，12例（22.2%）血清乙肝病毒脱氧核糖核酸（HBV - DNA）阳性。1例患者同时有anti - HDV和anti - HCV，另1例有anti - HCV和血清HBV - DNA。54例患者中有21例初诊时患有肝硬化，其中17例（81%）anti - HCV和/或anti - HDV阳性。总体而言，209例患者中有123例初诊时患有肝硬化，其中107例丙肝感染可能起了作用。
