慢性丙型肝炎血液透析患者隐匿性乙肝病毒感染的患病率
Prevalence of occult HBV infection in haemodialysis patients with chronic HCV.
作者信息
Goral Vedat, Ozkul Hamza, Tekes Selahattin, Sit Dede, Kadiroglu Ali Kemal
机构信息
Department of Gastroenterology, Dicle University School of Medicine, Diyarbakir, Turkey.
出版信息
World J Gastroenterol. 2006 Jun 7;12(21):3420-4. doi: 10.3748/wjg.v12.i21.3420.
Abstract
AIM
To study the prevalence and clinical effects of occult HBV infection in haemodialysis patients with chronic HCV.
METHODS
Fifty chronic hemodialysis patients with negative HbsAg, and positive anti-HCV were included in the study. These patients were divided into two groups: HCV-RNA positive and HCV-RNA negative, based on the results of HCV-RNA PCR. HBV-DNA was studied using the PCR method in both groups.
RESULTS
None of the 22 HCV-RNA positive patients and 28 HCV-RNA negative patients revealed HBV-DNA in serum by PCR method. The average age was 47.2 +/- 17.0 in the HCV-RNA positive group and 39.6 +/- 15.6 in the HCV-RNA negative group.
CONCLUSION
The prevalence of occult HBV infection is not high in haemodialysis patients with chronic HCV in our region. This result of our study has to be evaluated in consideration of the interaction between HBsAg positivity (8%-10%) and frequency of HBV mutants in our region.
摘要
目的
研究慢性丙型肝炎病毒（HCV）血液透析患者中隐匿性乙型肝炎病毒（HBV）感染的患病率及临床影响。
方法
纳入50例乙肝表面抗原（HbsAg）阴性且抗-HCV阳性的慢性血液透析患者。根据HCV-RNA聚合酶链反应（PCR）结果，将这些患者分为两组：HCV-RNA阳性组和HCV-RNA阴性组。两组均采用PCR法检测HBV-DNA。
结果
22例HCV-RNA阳性患者和28例HCV-RNA阴性患者中，通过PCR法均未在血清中检测到HBV-DNA。HCV-RNA阳性组的平均年龄为47.2±17.0岁，HCV-RNA阴性组的平均年龄为39.6±15.6岁。
结论
在我们地区，慢性HCV血液透析患者中隐匿性HBV感染的患病率不高。我们研究的这一结果必须结合我们地区HBsAg阳性率（8%-10%）和HBV突变频率之间的相互作用来评估。
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