Vasenius J, Vainionpää S, Vihtonen K, Mero M, Mäkelä A, Törmälä P, Rokkanen P
Department of Orthopaedics and Traumatology, Töölö Hospital, Helsinki, Finland.
J Biomed Mater Res. 1990 Dec;24(12):1615-35. doi: 10.1002/jbm.820241206.
A total of 150 osteotomies of rabbits' distal femur were fixed with absorbable self-reinforced polyglycolide (SR-PGA) rods coated with slowly absorbable polymers. In order to reduce the degradation rate of the SR-PGA construction rods were coated with n-butyl-2-cyanoacrylate, polydioxanone (PDS), poly-beta-hydroxybutyrate (PHBA), or poly-l-lactide (PLLA). Biocompatibility and the rate of biodegradation were evaluated in histological, histomorphometric, microradiographic, and oxytetracycline labeling studies. PDS, PHBA, and PLLA coatings showed good biocompatibility although there were scattered fluid accumulations around the rod in each group. Cyanoacrylate coating seemed to inhibit cartilage regeneration and cause the formation of considerable amount of connective tissue around the implant. The PGA core of the rod had totally degraded in 24 to 36 weeks in each coating group. Cyanoacrylate and PDS coatings were not detectable after 6 weeks while PHBA and PLLA coatings were still observed after 48 weeks. There were five (14%) non-unions in the cyanoacrylate coating group, one (3%) in the PHBA coating group caused by a purulent infection and none in the PDS and PLLA coating groups.
总共对150只兔的股骨远端进行截骨术，并用涂有缓慢吸收性聚合物的可吸收自增强聚乙交酯（SR-PGA）棒固定。为降低SR-PGA的降解速率，构建棒分别涂有正丁基-2-氰基丙烯酸酯、聚二氧六环酮（PDS）、聚-β-羟基丁酸酯（PHBA）或聚-L-丙交酯（PLLA）。通过组织学、组织形态计量学、显微放射照相术和土霉素标记研究评估生物相容性和生物降解速率。PDS、PHBA和PLLA涂层显示出良好的生物相容性，尽管每组棒周围都有散在的积液。氰基丙烯酸酯涂层似乎抑制软骨再生并导致植入物周围形成大量结缔组织。在每个涂层组中，棒的PGA核心在24至36周内完全降解。6周后检测不到氰基丙烯酸酯和PDS涂层，而48周后仍可观察到PHBA和PLLA涂层。氰基丙烯酸酯涂层组有5例（14%）骨不连，PHBA涂层组有1例（3%）因脓性感染导致骨不连，PDS和PLLA涂层组无骨不连。
