Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad, India.
Drug Chem Toxicol. 2012 Apr;35(2):184-91. doi: 10.3109/01480545.2011.589846. Epub 2012 Jan 25.
The present study was conducted to screen the efficacy of curcumin against chloroquine phosphate (CQ)-induced reproductive toxicity in adult male Swiss albino mice. Animals were given oral doses of 100, 200, 300 mg/kg body weight (b.w.), and high dose of CQ (300 mg/kg b.w.) + curcumin (80 mg/kg b.w.) for 45 days. Animals of the withdrawal group were given high dose of CQ (300 mg/kg b.w.) for 45 days and, at day 46, were kept for another 45 days. Effects were observed on some key enzymes, such as alkaline phosphatase, which was found to be decreased, whereas acid phosphatase was increased and succinate dehydrogenase and adenosine triphosphatase were decreased. Oxidative parameters, such as superoxide dismutase declined, whereas thiobarbituric acid-reactive substances were found to be elevated. Protein level was also decreased. Gravimetric indices were also recorded. Results obtained indicated adverse effects of CQ in a dose-dependent manner. The presence of curcumin with CQ alleviated its toxic effects. Hence, it can be concluded that curcumin has beneficial influences and appears able to ameliorate CQ toxicity.
本研究旨在筛选姜黄素对磷酸氯喹（CQ）诱导的成年雄性瑞士白化小鼠生殖毒性的疗效。动物给予 100、200、300mg/kg 体重（bw）的口服剂量，以及高剂量 CQ（300mg/kg bw）+姜黄素（80mg/kg bw）45 天。撤药组动物给予高剂量 CQ（300mg/kg bw）45 天，第 46 天再维持 45 天。观察到一些关键酶的影响，如碱性磷酸酶降低，而酸性磷酸酶升高，琥珀酸脱氢酶和三磷酸腺苷酶降低。氧化参数如超氧化物歧化酶下降，而硫代巴比妥酸反应物质升高。蛋白质水平也降低。体重指数也有记录。结果表明 CQ 呈剂量依赖性的不良反应。CQ 中存在姜黄素可减轻其毒性作用。因此，可以得出结论，姜黄素具有有益的影响，似乎能够改善 CQ 毒性。
