Department of Biochemistry, Faculty of Medicine, Marmara University, 34668 Haydarpasa, Istanbul, Turkey.
Curr Pharm Des. 2011;17(21):2215-20. doi: 10.2174/138161211796957436.
Tocotrienols, components belonging to vitamin E members, are used as potent therapeutics in the treatment of several diseases. Recent studies suggested tocotrienol to have better activity in many situations compared to tocopherols. Tocotrienols have been shown to lower the atherogenic apolipoprotein B and lipoprotein plasma levels. Additionally, tocotrienols with their anti-tumor effect together with anti-angiogenic and anti-thrombotic effects may serve as effective agents in cancer therapy. Besides these effects, some properties such as water insolubility and low stability limit the usage of tocotrienols in the clinic. However recent studies tried to increase the bioavailability with esterification and combination use. These efforts for the clinical usage of tocotrienols which may help them to take a wide place in the clinic and additional studies are needed to identify their therapeutical mechanisms.
生育三烯酚，维生素 E 族的成员之一，被用作多种疾病治疗的有效药物。最近的研究表明，生育三烯酚在许多情况下比生育酚具有更好的活性。生育三烯酚已被证明可以降低动脉粥样硬化的载脂蛋白 B 和脂蛋白血浆水平。此外，生育三烯酚具有抗肿瘤作用，以及抗血管生成和抗血栓形成作用，可作为癌症治疗的有效药物。除了这些作用外，一些性质，如不溶于水和低稳定性，限制了生育三烯酚在临床上的应用。然而，最近的研究试图通过酯化和联合使用来提高其生物利用度。这些为生育三烯酚的临床应用所做的努力可能有助于它们在临床上占据一席之地，还需要进一步的研究来确定它们的治疗机制。
