Cancer Science Institute of Singapore, National University of Singapore, 117599, Singapore.
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore.
Drug Discov Today. 2017 Dec;22(12):1765-1781. doi: 10.1016/j.drudis.2017.08.001. Epub 2017 Aug 5.
Vitamin E family members: tocotrienols and tocopherols are widely known for their health benefits. Decades of research on tocotrienols have shown they have diverse biological activities such as antioxidant, anti-inflammatory, anticancer, neuroprotective and skin protection benefits, as well as improved cognition, bone health, longevity and reduction of cholesterol levels in plasma. Tocotrienols also modulate several intracellular molecular targets and, most importantly, have been shown to improve lipid profiles, reduce total cholesterol and reduce the volume of white matter lesions in human clinical trials. This review provides a comprehensive update on the little-known therapeutic potentials of tocotrienols, which tocopherols lack in a variety of inflammation-driven diseases.
维生素 E 家族成员：生育三烯酚和生育酚以其对健康的益处而广为人知。对生育三烯酚的数十年研究表明，它们具有多种生物活性，如抗氧化、抗炎、抗癌、神经保护和皮肤保护作用，以及改善认知、骨骼健康、延长寿命和降低血浆胆固醇水平。生育三烯酚还调节几种细胞内分子靶标，最重要的是，已被证明可改善脂质谱，降低总胆固醇并减少人类临床试验中脑白质病变的体积。本综述全面介绍了生育三烯酚鲜为人知的治疗潜力，而生育酚在各种炎症驱动的疾病中缺乏这种潜力。
