Division of Paediatric Neurology, Children's Hospital Los Angeles, 4650 Sunset Boulevard, MS # 82, Los Angeles, CA 90027, USA.
Eur J Paediatr Neurol. 2012 Mar;16(2):138-41. doi: 10.1016/j.ejpn.2011.06.008. Epub 2011 Jul 19.
Frontal intermittent rhythmic delta activity (FIRDA) has been studied extensively in adults but published literature about its clinical correlates in children and adolescents is comparatively limited.
This study was performed to find more evidence regarding the clinical significance of this electrographic pattern in the pediatric population.
All electroencephalograms (EEGs) with FIRDA between 07/01/2006 and 12/31/2009 at our institution were identified. Clinical data were collected from charts of patients with FIRDA. A comparison group consisting of patients matched for age and location was assembled.
We identified 26 EEGs in 22 patients with this electrographic pattern from a total of 4627 EEGs. All 26 EEGs were performed because of a history of seizures or to rule out seizures. Two of the 22 patients did not have evaluable clinical data. Of the remaining, 18 had seizures. The events in 2 patients were determined to be non epileptic. Amongst the 18 patients with seizures, 10 had associated epileptiform discharges and only 2 were without epileptiform activity or localizing or lateralizing features. Two patients had brain tumor. Six patients had hydrocephalus. Three patients had encephalopathy due to anoxic, metabolic or infectious etiology. There was no statistically significant difference between the study and the comparison group for occurrence of brain tumor, hydrocephalus or encephalopathy.
FIRDA was uncommonly observed. It was associated with a variety of conditions and was not a specific marker of brain tumor, hydrocephalus or encephalopathy.
额部间歇性节律性 delta 活动（FIRDA）在成人中已得到广泛研究，但关于其在儿童和青少年中的临床相关性的文献相对较少。
本研究旨在为这一电图表型在儿科人群中的临床意义寻找更多证据。
本研究确定了 2006 年 7 月 1 日至 2009 年 12 月 31 日期间在我院进行的所有伴有 FIRDA 的脑电图（EEG）。从伴有 FIRDA 的患者图表中收集临床数据。我们组建了一个年龄和位置匹配的对照组。
在总共 4627 份脑电图中，我们从 22 名患者的 26 份脑电图中发现了这种脑电图模式。这 26 份脑电图均因癫痫发作史或为排除癫痫发作而进行。22 名患者中有 2 名没有可评估的临床数据。其余的 18 名患者中有癫痫发作。其中 2 名患者的事件被确定为非癫痫性。在 18 名癫痫发作的患者中，有 10 名伴有癫痫样放电，只有 2 名患者没有癫痫样活动或局灶性或偏侧性特征。2 名患者有脑瘤。6 名患者有脑积水。3 名患者因缺氧、代谢或感染性病因导致脑病。在脑瘤、脑积水或脑病的发生方面，研究组与对照组之间没有统计学上的显著差异。
FIRDA 不常见。它与多种疾病相关，不是脑瘤、脑积水或脑病的特异性标志物。
