van Niekerk Catharina C, Bulten Johan, Verbeek André L M
Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
ISRN Obstet Gynecol. 2011;2011:617082. doi: 10.5402/2011/617082. Epub 2011 Apr 10.
Background. Patients with epithelial ovarian cancer have a high risk of (non-)melanoma skin cancer. The association between histological variants of primary ovarian cancer and skin cancer is poorly documented. Objectives. To further evaluate the risk of skin cancer based on the histology of the epithelial ovarian cancer. Methods. A cross-sectional study within a large population-based dataset. Results. Skin cancer was found in 2.7% (95% CI: 2.3-3.1) of the 5366 individuals forming our dataset. The odds ratio (OR) for endometrioid cancer in the ovary to skin cancer in the under 50 age group was 8.9 (95% CI: 3.2-25.0). The OR decreased in older patients to 1.2. Conclusions. Patients with epithelial ovarian malignancies show an increased risk of skin cancer. A significantly increased risk (4.3%) for endometrioid ovarian cancer was found in the group aged under 50.
背景。上皮性卵巢癌患者患（非）黑色素瘤皮肤癌的风险较高。原发性卵巢癌组织学亚型与皮肤癌之间的关联记录较少。目的。根据上皮性卵巢癌的组织学进一步评估皮肤癌风险。方法。在一个基于人群的大型数据集中进行横断面研究。结果。在构成我们数据集的5366名个体中，2.7%（95%置信区间：2.3 - 3.1）被发现患有皮肤癌。50岁以下年龄组中卵巢子宫内膜样癌与皮肤癌的比值比（OR）为8.9（95%置信区间：3.2 - 25.0）。老年患者的OR降至1.2。结论。上皮性卵巢恶性肿瘤患者患皮肤癌的风险增加。在50岁以下年龄组中，子宫内膜样卵巢癌的风险显著增加（4.3%）。
