Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Rolighedsvej 30, DK-1958 Frederiksberg C, Denmark.
Appetite. 2011 Dec;57(3):601-4. doi: 10.1016/j.appet.2011.07.004. Epub 2011 Jul 14.
This randomized, controlled, 2-week intervention study in 24 obese subjects tested the effect on body weight loss and gastrointestinal tolerance of consuming low viscous alginate fibre-based preloads of 3% concentration (500 ml volume) three times a day as an adjuvant to a calorie-restricted diet. The pilot study showed that intake of the alginate preloads was moderately acceptable to the majority of subjects but did not produce additional body weight loss beyond calorie restriction (-1.42 ± 0.38 kg) (n=12) compared to control group (-1.56 ± 0.21 kg) (n=8). These results do not support that alginate supplementation enhance the weight loss effects of a hypo-caloric diet, but a sufficiently powered long-term study is needed to explore whether alginate could be an aid for improving weight loss during caloric-restriction.
本研究为随机对照双盲干预性试验，共纳入 24 名肥胖受试者，旨在测试低粘性藻酸盐纤维预负荷（浓度 3%，500ml 容量）作为热量限制饮食的辅助治疗，每日三次，连续 2 周，对体重减轻和胃肠道耐受性的影响。初步研究表明，对于大多数受试者而言，藻酸盐预负荷的摄入具有中等可接受性，但与对照组（n=8）相比，除了热量限制（-1.56±0.21kg）之外，并未额外产生体重减轻（-1.42±0.38kg）（n=12）。这些结果不支持藻酸盐补充可增强低热量饮食的减肥效果，但需要进行足够大样本量的长期研究，以探讨藻酸盐是否可作为热量限制期间减肥的辅助手段。
