Department of Human Nutrition, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark.
Am J Clin Nutr. 2012 Jul;96(1):5-13. doi: 10.3945/ajcn.111.025312. Epub 2012 May 30.
Acute studies with alginate-based preloads suggested that these strong gelling fibers may induce increased feelings of satiety and reduce energy intakes. However, the long-term efficacy and safety of alginate supplementation on body weight regulation are lacking.
The primary aim of the study was to investigate the effects in subjects of alginate supplementation in conjunction with energy restriction (-300 kcal/d) on loss of body weight and fat and, second, on metabolic risk markers in comparison with in a placebo group.
In a parallel, double-blind, placebo-controlled study, we randomly assigned 96 obese subjects to either an energy-restricted diet plus a placebo preload supplement or an energy-restricted diet plus an alginate-based preload supplement (15 g fiber). The preload was administered as a beverage 3 times/d before main meals for a period of 12 wk.
No differences in loss of body weight and fat between groups were shown in the intension-to-treat (ITT) analysis (P > 0.1). However, in the completer analysis (n = 80), we showed a greater weight loss with alginate (6.78 ± 3.67 kg) than with the placebo (5.04 ± 3.40 kg) (P = 0.03), which was mainly attributed to a reduction in the percentage of body fat (P = 0.03). In the ITT analysis, a larger decrease in systolic and diastolic blood pressure was shown in the placebo group than in the alginate group (P < 0.05). Plasma concentrations of glucose, insulin, C-reactive protein, and ghrelin, HOMA-IR, and lipid metabolism did not differ between treatment groups in the ITT analysis (P > 0.1).
These results suggest that alginate supplementation as an adjunct to energy restriction may improve weight loss in obese subjects who complete a 12-wk dietary intervention.
急性海藻酸盐负荷研究表明，这些强力凝胶纤维可能会增加饱腹感，减少能量摄入。然而，关于海藻酸盐补充剂对体重调节的长期疗效和安全性尚不清楚。
本研究的主要目的是研究在能量限制（-300 千卡/天）的情况下，与安慰剂组相比，海藻酸盐补充剂联合能量限制对体重和体脂减轻的影响，其次是对代谢风险标志物的影响。
在一项平行、双盲、安慰剂对照研究中，我们将 96 名肥胖受试者随机分为能量限制饮食加安慰剂预负荷补充组或能量限制饮食加海藻酸盐基预负荷补充组（15 克纤维）。预负荷以饮料的形式在主餐前 3 次/天给予，持续 12 周。
意向治疗（ITT）分析显示，两组间体重和体脂减轻无差异（P>0.1）。然而，在完成分析（n=80）中，我们发现海藻酸盐组体重减轻（6.78±3.67kg）大于安慰剂组（5.04±3.40kg）（P=0.03），这主要归因于体脂百分比的降低（P=0.03）。在 ITT 分析中，安慰剂组的收缩压和舒张压下降幅度大于海藻酸盐组（P<0.05）。在 ITT 分析中，两组间血糖、胰岛素、C 反应蛋白、ghrelin、HOMA-IR 和脂代谢的血浆浓度无差异（P>0.1）。
这些结果表明，海藻酸盐补充剂作为能量限制的辅助手段，可能会改善完成 12 周饮食干预的肥胖受试者的体重减轻。
