Suppr超能文献

冻结步态:神秘临床现象的前行

Freezing of gait: moving forward on a mysterious clinical phenomenon.

机构信息

Department of Neurology, Oregon Health & Science University, Portland, OR 97239, USA.

出版信息

Lancet Neurol. 2011 Aug;10(8):734-44. doi: 10.1016/S1474-4422(11)70143-0.

Abstract

Freezing of gait (FoG) is a unique and disabling clinical phenomenon characterised by brief episodes of inability to step or by extremely short steps that typically occur on initiating gait or on turning while walking. Patients with FoG, which is a feature of parkinsonian syndromes, show variability in gait metrics between FoG episodes and a substantial reduction in step length with frequent trembling of the legs during FoG episodes. Physiological, functional imaging, and clinical-pathological studies point to disturbances in frontal cortical regions, the basal ganglia, and the midbrain locomotor region as the probable origins of FoG. Medications, deep brain stimulation, and rehabilitation techniques can alleviate symptoms of FoG in some patients, but these treatments lack efficacy in patients with advanced FoG. A better understanding of the phenomenon is needed to aid the development of effective therapeutic strategies.

摘要

冻结步态(Freezing of gait,FoG)是一种独特且使人致残的临床现象,其特征是短暂的无法迈步或极短的步伐,通常发生在开始行走或行走中转弯时。冻结步态是帕金森综合征的特征之一,患者在步态指标上表现出发作间的可变性,并且在发作期间腿部经常颤抖,导致步长显著缩短。生理、功能成像和临床病理学研究表明,额叶皮质区域、基底神经节和中脑运动区域的紊乱可能是冻结步态的起源。药物治疗、深部脑刺激和康复技术可以缓解一些患者的冻结步态症状,但这些治疗方法对晚期冻结步态患者疗效欠佳。为了帮助开发有效的治疗策略,需要更好地了解这一现象。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc06/7293393/ff3c07cee967/nihms-1594563-f0001.jpg

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验