Center for Nuclear Receptors and Cell Signalling, Department of Biology and Biochemistry, University of Houston, Houston 77204, Texas, USA.
Nat Rev Cancer. 2011 Jul 22;11(8):597-608. doi: 10.1038/nrc3093.
By eliciting distinct transcriptional responses, the oestrogen receptors (ERs) ERα and ERβ exert opposite effects on cellular processes that include proliferation, apoptosis and migration and that differentially influence the development and the progression of cancer. Perturbation of ER subtype-specific expression has been detected in various types of cancer, and the differences in the expression of ERs are correlated with the clinical outcome. The changes in the bioavailability of ERs in tumours, together with their specific biological functions, promote the selective restoration of their activity as one of the major therapeutic approaches for hormone-dependent cancers.
通过引发不同的转录反应，雌激素受体 (ERs) ERα 和 ERβ 对包括增殖、凋亡和迁移在内的细胞过程产生相反的影响，并对癌症的发展和进展产生不同的影响。在各种类型的癌症中都检测到 ER 亚型特异性表达的扰动，并且 ERs 的表达差异与临床结果相关。肿瘤中 ER 生物利用度的变化及其特定的生物学功能，促进了其活性的选择性恢复，这是激素依赖性癌症的主要治疗方法之一。
