Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Obesity (Silver Spring). 2011 Dec;19(12):2436-9. doi: 10.1038/oby.2011.237. Epub 2011 Jul 21.
Obesity is a serious health concern for children and adolescents, particularly in Western societies, where its incidence is now considered to have reached epidemic proportions. A number of genetic determinants of adult BMI have already been established through genome wide association studies (GWAS), most recently from the GIANT meta-analysis of such datasets combined. In this current study of European Americans, we examined the 32 loci detected in that GIANT study in the context of common childhood obesity within a cohort of 1,097 cases (defined as BMI ≥95th percentile), together with 2,760 lean controls (defined as BMI <50th percentile), aged between 2 and 18 years old. Nine of these single-nucleotide polymorphims (SNPs) yielded at least nominal evidence for association with common childhood obesity, namely at the FTO, TMEM18, NRXN3, MC4R, SEC16B, GNPDA2, TNNI3K, QPCTL, and BDNF loci. However, overall 28 of the 32 loci showed directionally consistent effects to that of the adult BMI meta-analysis. We conclude that among the 32 loci that have been reported to associate with adult BMI in the largest meta-analysis of BMI to date, at least nine also contribute to the determination of common obesity in childhood in European Americans, as demonstrated by their associations in our pediatric cohort.
肥胖是儿童和青少年的一个严重健康问题，尤其是在西方社会，肥胖的发病率现在被认为已经达到了流行的程度。通过全基因组关联研究（GWAS）已经确定了一些成人 BMI 的遗传决定因素，最近的研究结果来自对这些数据集的 GIANT 荟萃分析。在这项对欧洲裔美国人的研究中，我们在一个包含 1097 例病例（定义为 BMI≥95 百分位数）的队列中，研究了 GIANT 研究中检测到的 32 个位点，这些病例均患有常见的儿童肥胖症，同时还包括 2760 名瘦对照者（定义为 BMI<50 百分位数），年龄在 2 至 18 岁之间。这些单核苷酸多态性（SNPs）中有 9 个至少在名义上与常见的儿童肥胖症有关，即 FTO、TMEM18、NRXN3、MC4R、SEC16B、GNPDA2、TNNI3K、QPCTL 和 BDNF 基因座。然而，32 个基因座中的 28 个整体表现出与成人 BMI 荟萃分析一致的方向效应。我们得出结论，在迄今为止最大的 BMI 荟萃分析中，与成人 BMI 相关的 32 个基因座中，至少有 9 个也有助于确定欧洲裔美国儿童中常见的肥胖症，这是通过我们儿科队列中的关联得到证明的。
