Goulet Danick, O'Loughlin Jennifer, Sylvestre Marie-Pierre
École de santé publique, Université de Montréal, Montréal, QC, Canada.
Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada.
Front Genet. 2021 Sep 1;12:690335. doi: 10.3389/fgene.2021.690335. eCollection 2021.
The strong correlation between adiposity and blood pressure (BP) might be explained in part by shared genetic risk factors. A recent study identified three nucleotide variants [rs16933812 (), rs7638110 (), and rs9930333 ()] associated with both body mass index (BMI) and systolic blood pressure (SBP) in adolescents age 12-18years. We attempted to replicate these findings in a sample of adolescents of similar age. A total of 713 adolescents were genotyped and had anthropometric indicators and blood pressure measured at age 13, 15, 17, and 24years. Using linear mixed models, we assessed associations of these variants with BMI and SBP. In our data, rs9930333 () was associated with body mass index, but not systolic blood pressure. Neither rs16933812 () nor rs7638110 () were associated with body mass index or systolic blood pressure. Although, differences in phenotypic definitions and in genetic architecture across populations may explain some of the discrepancy across studies, nucleotide variant selection in the initial study may have led to false-positive results that could not be replicated.
肥胖与血压（BP）之间的强相关性可能部分由共同的遗传风险因素来解释。最近一项研究在12至18岁的青少年中确定了三个与体重指数（BMI）和收缩压（SBP）均相关的核苷酸变体[rs16933812（）、rs7638110（）和rs9930333（）]。我们试图在年龄相仿的青少年样本中重现这些发现。共有713名青少年进行了基因分型，并在13、15、17和24岁时测量了人体测量指标和血压。使用线性混合模型，我们评估了这些变体与BMI和SBP的关联。在我们的数据中，rs9930333（）与体重指数相关，但与收缩压无关。rs16933812（）和rs7638110（）均与体重指数或收缩压无关。尽管不同人群之间表型定义和遗传结构的差异可能解释了不同研究之间的一些差异，但最初研究中的核苷酸变体选择可能导致了无法重现的假阳性结果。
