Rossoni Carina, Bisi Melissa Cláudia, Keiserman Mauro Waldemar, Staub Henrique Luiz
Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul – PUC-RS, Brazil.
Rev Bras Reumatol. 2011 Jul-Aug;51(4):383-4, 386-7.
A beneficial influence of antimalarials on lipid profile of systemic lupus erythematosus (SLE) patients has been recently claimed. In this cross-sectional study, we evaluated the effect of chloroquine on cholesterol levels of a Brazilian population with SLE. Sixty patients were studied, 95% females. Mean age was 48.7 years (SD 13.3 years). Overweight or obesity was documented in 27 cases (45%). Thirty-four patients (56.6%) were using chloroquine in standard dosage, while 33 (55%) were on corticosteroids. Hypercholesterolemia was present in 26 patients (43.3%), while low HDL cholesterol levels were seen in 18 cases (30%). Normal cholesterolemia was documented equally in users and non-users of antimalarials (P > 0.20). After adjustment for statin and corticosteroid intake by multivariate analysis, cholesterol and HDL-cholesterol levels did not significantly differ in users or non-users of chloroquine (P > 0.05). There was no association of chloroquine intake with low body mass index (P = 0.314). Our findings suggest that antimalarial intake by itself does not distinguish cholesterol profiles in SLE patients.
最近有人声称抗疟药对系统性红斑狼疮（SLE）患者的血脂状况有有益影响。在这项横断面研究中，我们评估了氯喹对巴西SLE患者胆固醇水平的影响。研究了60例患者，其中95%为女性。平均年龄为48.7岁（标准差13.3岁）。27例（45%）有超重或肥胖记录。34例患者（56.6%）正在使用标准剂量的氯喹，而33例（55%）正在使用皮质类固醇。26例患者（43.3%）存在高胆固醇血症，18例（30%）出现低高密度脂蛋白胆固醇水平。抗疟药使用者和非使用者的胆固醇血症正常情况相同（P>0.20）。通过多变量分析调整他汀类药物和皮质类固醇的摄入量后,氯喹使用者和非使用者的胆固醇和高密度脂蛋白胆固醇水平无显著差异（P>0.05）。氯喹摄入量与低体重指数无关联（P=0.314）。我们的研究结果表明，单独服用抗疟药并不能区分SLE患者的胆固醇谱。
