Rudnicki R D, Gresham G E, Rothfield N F
J Rheumatol. 1975 Sep;2(3):323-30.
Of 209 patients who fulfilled the A.R.A. criteria for the diagnosis of systemic lupus erythematosus, 43 were selected for study because each had been treated for at least two years with antimalarials, but had not received antimalarials for at least one subsequent year. In each instance, the antimalarial was discontinued solely because of the development of retinopathy. Each year on antimalarials was matched with a subsequent year off antimalarials for each patient. The year immediately following diagnosis and years of pregnancy were excluded. Paired-t test analysis of matched years revealed that general symptoms (fever, fatigue, weight loss) were less common during years on 500 mg chloroquine daily than during years off the drug (p less than 0.05). Skin manifestations were also less frequent during the years on 500 mg chloroquine daily than during the years off (p less than 0.05). No significant steroid sparing effect was found. However, a greater incidence of flare-ups during the matched years off the drug was statistically significant.
在209例符合美国风湿病学会（A.R.A.）系统性红斑狼疮诊断标准的患者中，43例被选入研究，因为他们每人都接受了至少两年的抗疟药治疗，但随后至少有一年未接受抗疟药治疗。在每种情况下，停用抗疟药完全是因为出现了视网膜病变。为每位患者将服用抗疟药的每一年与随后未服用抗疟药的一年进行匹配。诊断后的紧接着那一年以及妊娠年份被排除。对匹配年份进行配对t检验分析显示，每日服用500毫克氯喹的年份中，一般症状（发热、疲劳、体重减轻）比未服用该药的年份少见（p<0.05）。每日服用500毫克氯喹的年份中皮肤表现也比未服用的年份少见（p<0.05）。未发现明显的激素节省效应。然而，在未服用药物的匹配年份中病情复发的发生率更高，具有统计学意义。
