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[婴儿沙门氏菌胃肠炎的回顾性研究]

[Retrospective study of Salmonella gastroenteritis in infants].

作者信息

Sheu C L, Wu T C, Hwang B T

机构信息

Department of Pediatrics, Veterans General Hospital, Taipei, R.O.C.

出版信息

Zhonghua Yi Xue Za Zhi (Taipei). 1990 Oct;46(4):232-6.

PMID:2178057
Abstract

UNLABELLED

Sixty-four cases of Salmonellosis were retrospectively analyzed in Jan. 1985 to Dec. 1988 at the department of pediatrics, Veteran General Hospital, Taipei. Most of the cases (78%) occurred between May and October, the most common pathogenic organism isolated was B salmonella group (65.6%). Antibiotic susceptibility to ampicillin revealed remarkably decrease from 75% (1985) down to 11.7% (1988) and the most sensitive antibiotic agent was ceftriaxone (98.3%). Blood culture were obtained in 42 cases and patients with salmonella bacteremia were found in 10 cases (23.8%). Five of 17 patients under 3 month old showed positive blood culture. Four of 5 bacteremic patients were complicated individually with convulsion, failure to thrive, chronic diarrhea and one case expired. Four of 33 patients between 3 month and 1 year were bacteremic. Two of 4 bacteremic patients were respectively complicated with meningitis and hip-joint arthritis. The average duration of salmonella shedding was 37.5 days (range 4-180 days).

IN CONCLUSION

  1. Salmonellosis hasn't decreased in the past 4 years and the resistance to ampicillin and chloramphenicol has increased. 2. Young infants are at particular risk for bacteremia and focal complication, so if salmonellosis is suspected in infants under 3 month old, blood culture should be obtained and proper antibiotic therapy should be given.
摘要

未加标注

1985年1月至1988年12月,台北荣民总医院儿科对64例沙门氏菌病病例进行了回顾性分析。大多数病例(78%)发生在5月至10月,分离出的最常见致病微生物是B组沙门氏菌(65.6%)。对氨苄西林的抗生素敏感性从1985年的75%显著下降至1988年的11.7%,最敏感的抗生素是头孢曲松(98.3%)。42例进行了血培养,10例(23.8%)发现有沙门氏菌血症患者。17例3个月以下患者中有5例血培养呈阳性。5例菌血症患者中有4例分别并发惊厥、发育不良、慢性腹泻,1例死亡。33例3个月至1岁患者中有4例菌血症。4例菌血症患者中有2例分别并发脑膜炎和髋关节关节炎。沙门氏菌排出的平均持续时间为37.5天(范围4 - 180天)。

结论

  1. 沙门氏菌病在过去4年中并未减少,对氨苄西林和氯霉素的耐药性增加。2. 幼儿患菌血症和局部并发症的风险特别高,因此如果怀疑3个月以下婴儿患有沙门氏菌病,应进行血培养并给予适当的抗生素治疗。

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