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[催产素在未孕大鼠子宫体和输卵管自发电活动激活中的作用]

[Role of oxytocin in activation of spontaneous electrical activity of uterine body and uterine tubes in non-pregnant rats].

作者信息

Kazarian K V, Unanian N G, Meliksetian I B, Akopian R R, Saakian A A

出版信息

Zh Evol Biokhim Fiziol. 2011 May-Jun;47(3):239-45.

PMID:21780644
Abstract

The work studies effects of various doses of oxytocin (0.01, 0.1, 1 and 10 microg/kg) on duration of discharges of spontaneous electrical activity and frequency of spikes in various parts of uterine tubes and of uterine body of non-pregnant rats. Under these conditions, changes in these parameters for ovarian parts of the uterine tubes had similar character unlike those in cervical parts of the tubes and in the middle part of the uterine body, so the latter parts can be grouped together owing to peculiarities of their changes. The longest duration of genesis of electric discharges has been shown for the ovarian part of uterine tubes at a concentration of 10 microg/kg of oxytocin. Morphological experiments revealed that among all studies areas the ovarian parts of uterine tubes were characterized by the highest amount of atypical cells that have the maximally pronounced functional activity.

摘要

该研究探讨了不同剂量催产素(0.01、0.1、1和10微克/千克)对未孕大鼠输卵管各部位及子宫体自发电活动放电持续时间和尖峰频率的影响。在这些条件下,输卵管卵巢部分这些参数的变化具有相似特征,这与输卵管宫颈部分和子宫体中部不同,因此后两个部分因其变化特点可归为一组。已表明,当催产素浓度为10微克/千克时,输卵管卵巢部分的放电发生持续时间最长。形态学实验显示,在所有研究区域中,输卵管卵巢部分的非典型细胞数量最多,其功能活性最为显著。

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