Sukhanov D S, Vinogradova T I, Zabolotnykh N V, Kovalenko A L, Vasil'eva S N, Romantsov M G
Antibiot Khimioter. 2011;56(1-2):13-7.
The hepatoprotective activity of remaxol, reamberin and ademethionine was studied on a model of the liver injury induced by antituberculosis drugs. The study included 30 male uninbred albino rats. The following antituberculosis drugs were used: isoniazid (50 mg/kg) subcutaneously + rifampicin (250 mg/kg) intragastrically + pyrazinamide (45 mg/kg) intragastically (by the procedure of Yu. I. Slivka, 1989). Remaxol, reamberin and ademethionine were administered 1.5 hour prior to the antituberculosis drugs. The treatment course was 14 days. It was shown that remaxol, reamberin and ademethionin were able to correct the structural and functional disorders in the liver due to the use of the antituberculosis drugs. By the impact on the biochemical indices, evident of the liver function condition, remaxol showed the maximum effect. The effect of ream-berin was somewhat lower and the results of the ademethionine use were less significant. Remaxol had also a distinct effect as for lowering the level of the structural injuries in the liver, evident from recovery of the organ histoarchitectonics, less extended carbohydrate, albuminous and fatty degeneration, more active intracellular regeneration. It was noted that ademethionine had an insignificant effect on necrobiosis. Moreover, there was once detected a large necrosis focus, evident of possible stimulation of the liver tissue alteration by the drug.
在抗结核药物所致肝损伤模型上研究了雷马克索、雷安贝林和腺苷蛋氨酸的保肝活性。该研究纳入了30只未选育的雄性白化大鼠。使用了以下抗结核药物：皮下注射异烟肼（50毫克/千克）+胃内给予利福平（250毫克/千克）+胃内给予吡嗪酰胺（45毫克/千克）（按照尤·伊·斯利夫卡1989年的方法）。雷马克索、雷安贝林和腺苷蛋氨酸在给予抗结核药物前1.5小时给药。疗程为14天。结果表明，雷马克索、雷安贝林和腺苷蛋氨酸能够纠正因使用抗结核药物而导致的肝脏结构和功能紊乱。通过对反映肝功能状况的生化指标的影响来看，雷马克索显示出最大效果。雷安贝林的效果稍低，而使用腺苷蛋氨酸的结果不太显著。雷马克索在降低肝脏结构损伤水平方面也有明显作用，这从器官组织形态结构的恢复、碳水化合物、白蛋白和脂肪变性扩展程度减轻以及细胞内再生更活跃可以看出。值得注意的是，腺苷蛋氨酸对坏死作用不显著。此外，曾检测到一个大的坏死灶，这表明该药物可能刺激肝组织改变。
